In a recent post, biohacker and entrepreneur Dave Asprey shared his personal top 10 list of supplements he uses daily to support energy, focus, and longevity—highlighting the role targeted supplementation plays in optimizing human performance.

“The right supplements can upgrade your brain, body, and biology,” wrote Dave Asprey in a post on his blog.

Asprey’s list includes well-known essentials like magnesium, vitamin D3, and fish oil, along with more specialized compounds such as NMN (a precursor to NAD+ for mitochondrial health), CoQ10, and molecular hydrogen. Each choice is based on research-backed benefits for cognition, cellular repair, and metabolic function.

He also recommended activated charcoal for detoxification, noting its ability to bind to toxins in the gut, and emphasized the use of ketone esters for brain fuel and focus. Many of the supplements align with his broader strategy of reducing inflammation, enhancing energy production, and slowing the aging process.

Asprey, a longtime advocate of biohacking, views supplementation not as a shortcut but as a precision tool to close nutritional gaps, counter environmental stressors, and gain a performance edge.

Dave Asprey is the founder of Bulletproof and Upgrade Labs and a four-time New York Times bestselling author. Often referred to as the “father of biohacking,” he promotes a systems-thinking approach to health that integrates science, technology, and personalized data.